Enzymes in cancer

Flavin-Dependent Enzymes in Cancer Prevention

Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last decade, many papers concerning their structure, reaction mechanism and role in t...

More on serum enzymes in cancer patients.

10. Weissberg, J. B., Lipschutz, F. and Oski, F. A., #{244}-Aminolevulinic acid dehydratase activity in circulating blood cells: A sensitive laboratory test for the detection of childhood lead poisoning. N. Engi. J. Med. 284, 565 (1971). 11. Davis, J. R., and Avrani, M. J., Developmental changes in delta-aminolevulinic acid dehydratase (ALAD) activity and blood reticulocyte percent in the devel...

Chromatin-modifying enzymes in transcription and cancer

In recent years, our view of how gene expression is controlled has changed dramatically. The discovery of enzymes that modify histones has revealed that transcription is an enzymically driven process. Such modifications can recruit specific proteins and mediate chromatin changes that affect transcription either positively or negatively. Important biological pathways leading to cell proliferatio...

Dysregulated Expression and Sub cellular Localization of Base Excision Repair (BER) Pathway Enzymes in Gallbladder Cancer

Base excision repair (BER) pathway is one of the repair systems that have an impact on the radiotherapy and chemotherapy for the cancer patients. The molecular pathogenesis of gallbladder cancer is not known extensively. In the present study we investigated whether the expression of AP endonuclease 1 (APE1) and DNA polymerase β (DNA pol β), key enzymes of BER pathway has any clinical ...

Pharmacogenetics of Cancer and DNA Repair Enzymes